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Medicines > classes : Phenethylamine or Stimulant or [[:Category:SGLT2_inhibitors|SGLT2 inhibitor]]

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generic:
brand:
None (67) · Benzedrex (1) · Farxiga (US), Forxiga (international) (1) · Jardiance (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (12) · Monoamine releasing agent (8) · Dopamine/norepinephrine reuptake inhibitor (5) · Potent 5-HT2A agonist (5) · None (2) · Cathinone analogue; monoamine reuptake inhibitor (2) · Dopamine and norepinephrine reuptake inhibitor (2) · Norepinephrine–dopamine reuptake inhibitor (2)
uses:
None (69) · '"`UNIQ--vote-00000278-QINU`"', '"`UNIQ--vote-00000279-QINU`"', '"`UNIQ--vote-0000027A-QINU`"', '"`UNIQ--vote-0000027B-QINU`"' (1) · '"`UNIQ--vote-0000054E-QINU`"', '"`UNIQ--vote-0000054F-QINU`"', '"`UNIQ--vote-00000550-QINU`"', '"`UNIQ--vote-00000551-QINU`"' (1)
starting dose:
None (69) · 10 mg PO once daily in the morning; 5 mg starting in heart failure (1) · 10 mg PO once daily in the morning; may titrate to 25 mg for additional glycemic effect (1)
preparations:
None (69) · 10 mg, 25 mg tablets (1) · 5 mg, 10 mg tablets (1)
fda max:
None (69) · 10 mg/d (1) · 25 mg/d (1)
routes:
None (68) · insufflated (1) · Oral (3) · PR (1)
onset:
None (68) · 45-75 min (oral) (1) · Glycosuria within hours; HbA1c effect at 12 weeks; cardiovascular and renal benefits over months (1) · Glycosuria within hours; HbA1c effect at 12 weeks; CV/renal benefits over months (1)
duration:
None (68) · 24 hours (2) · 4-8 h (1)
halflife:
None (68) · Not well characterized (1) · ~12.4 hours'"`UNIQ--ref-0000027C-QINU`"' (1) · ~12.9 hours'"`UNIQ--ref-00000552-QINU`"' (1)
bioavailability:
None (68) · High (oral; not affected by food, but typically given with the morning meal)'"`UNIQ--ref-0000027D-QINU`"' (1) · Not well characterized (1) · ~78% (oral; high-fat meal modestly reduces but is not clinically significant)'"`UNIQ--ref-00000553-QINU`"' (1)
pregnancy:
None (68) · Avoid in second and third trimesters; fetal SGLT2 inhibition disrupts kidney development.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (2) · Not established (1)
legal:
None (68) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US (2)

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