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Medicines > classes : Phenethylamine or Stimulant or [[:Category:Tremor medicines|Tremor medicine]]

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generic:
brand:
None (67) · Benzedrex (1) · Mysoline (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (12) · Monoamine releasing agent (8) · Dopamine/norepinephrine reuptake inhibitor (5) · Potent 5-HT2A agonist (5) · Cathinone analogue; monoamine reuptake inhibitor (2) · Dopamine and norepinephrine reuptake inhibitor (2) · Norepinephrine–dopamine reuptake inhibitor (2)
uses:
None (69) · '"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"' (1)
starting dose:
None (69) · Seizures: 100-125 mg PO at bedtime x 3 days, then BID, then TID, escalating to 750-1500 mg/day. Essential tremor: 25-50 mg PO at bedtime, titrate slowly to 250-750 mg/day (1)
preparations:
None (69) · Tablets 50, 250 mg (1)
fda max:
None (69) · 2 g/day (seizures); typically much lower for essential tremor (1)
routes:
None (68) · insufflated (1) · Oral (2) · PR (1)
onset:
None (68) · 45-75 min (oral) (1) · Anticonvulsant effect emerges with slow titration over weeks; tremor effect over weeks (1)
duration:
None (68) · 4-8 h (1) · BID-TID dosing (1)
halflife:
None (68) · Not well characterized (1) · Primidone 5-15 hours; '''phenobarbital active metabolite 50-150 hours'''; PEMA (phenylethylmalonamide) active metabolite 16 hours'"`UNIQ--ref-00000017-QINU`"' (1)
bioavailability:
None (68) · Not well characterized (1) · ~90% (oral)'"`UNIQ--ref-00000018-QINU`"' (1)
pregnancy:
None (68) · Not established (1) · Substantial teratogenic signal (barbiturate class effects including neonatal withdrawal and hemorrhagic disease of newborn).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (68) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US. '''Federally non-controlled despite being a barbiturate''', a paradoxical situation given that its primary active metabolite phenobarbital is Schedule IV'"`UNIQ--ref-00000019-QINU`"' (1)

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