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Medicines > classes : Plant Medicine or [[:Category:Antihypertensives|Antihypertensive]] & fda max: 50 mg BID in heart failure (or once-daily equivalent CR); 25 mg BID in hypertension

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generic:
Carvedilol (1)
brand:
Coreg, Coreg CR (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-00000015-QINU`"' CYP2D6 metabolism produces stereoselective clearance; CYP2D6 poor metabolizers have higher plasma exposure and may need lower doses'"`UNIQ--ref-00000016-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000017-QINU`"', '"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"' (1)
starting dose:
Heart failure: 3.125 mg PO BID, doubling every 2 weeks as tolerated to target 25 mg BID (50 mg BID if >85 kg). Hypertension: 6.25 mg PO BID, titrate to 25 mg BID (1)
preparations:
IR tablets 3.125, 6.25, 12.5, 25 mg; Coreg CR capsules 10, 20, 40, 80 mg (once-daily) (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Antihypertensive effect within 1 week; heart-failure mortality benefit accrues over months of titration (1)
duration:
~12 hours (IR); 24 hours (CR) (1)
halflife:
7-10 hours'"`UNIQ--ref-0000001B-QINU`"' (1)
bioavailability:
~25-35% (extensive first-pass), increased by food which slows absorption and reduces orthostatic risk'"`UNIQ--ref-0000001C-QINU`"' (1)
pregnancy:
Limited human data; β-blocker class effects include fetal growth restriction and neonatal bradycardia/hypoglycemia.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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