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Medicines > classes : Plant Medicine or [[:Category:Polyene_antifungals|Polyene antifungal]] & routes: topical

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generic:
Atropa belladonna (1) · Nystatin (1)
brand:
Deadly nightshade (1) · Mycostatin, Nystop, Nyamyc, Bio-Statin (1)
classes: (Click arrow to add another value)
mechanism:
Tropane alkaloids: hyoscyamine (dominant; the racemic form is atropine), scopolamine. Competitive muscarinic antagonism. (1) · '"`UNIQ--vote-00000D11-QINU`"' Same mechanistic family as amphotericin B but with prohibitive systemic toxicity at therapeutic doses, hence restriction to topical and luminal-gut indications. No clinically meaningful resistance after decades of use'"`UNIQ--ref-00000D12-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000008-QINU`"', '"`UNIQ--vote-00000009-QINU`"' (1) · '"`UNIQ--vote-00000D13-QINU`"', '"`UNIQ--vote-00000D14-QINU`"', '"`UNIQ--vote-00000D15-QINU`"', '"`UNIQ--vote-00000D16-QINU`"' (1)
starting dose:
None (1) · Oral: 4-6 mL (400,000-600,000 units) suspension QID swish-and-swallow; topical: BID-QID; vaginal tablet 1 daily for 2 weeks (1)
preparations:
100,000 units/mL oral suspension; 500,000 unit tablets; 100,000 units/g cream, ointment, powder; vaginal tablets (1) · Leaves, berries, root. Historically: belladonna cigarettes ("Asthmador") OTC in US until the 1970s (1)
fda max:
None (1) · Indication-specific (1)
routes: (Click arrow to add another value)
onset:
None (1) · Symptom relief within days (1)
duration:
None (1) · Hours per application (1)
halflife:
None (1) · Not meaningfully described (not systemically absorbed)'"`UNIQ--ref-00000D17-QINU`"' (1)
bioavailability:
None (1) · Essentially zero systemic absorption from oral or topical routes — the topical-action-only profile is the basis of its safety'"`UNIQ--ref-00000D18-QINU`"' (1)
pregnancy:
None (1) · Generally considered safe in pregnancy (no systemic absorption).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
Plant unrestricted; pharmaceutical atropine Rx-only (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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