Drilldown: Medicines
Use the filters below to narrow your results.
generic:
Artemisia absinthium (1) ·
Atropa belladonna (1) ·
Banisteriopsis caapi (1) ·
Black Drink (1) ·
Brugmansia (1) ·
Chocolate (1) ·
Coffee (1) ·
Dextromethorphan / Quinidine (1) ·
Guarana (1) ·
Hyoscyamus niger (1) ·
Kola (1) ·
Mandragora officinarum (1) ·
Mescal Bean (1) ·
Tea (1) ·
Tramadol / Acetaminophen (1) ·
Yerba mate (1)
brand:
''Brugmansia'' spp., Angel's trumpet, ''borrachero'', ''toé'' (1) ·
''Camellia sinensis'' (formerly ''Thea sinensis'') (1) ·
''Coffea arabica'', ''Coffea canephora'' (robusta) (1) ·
''Cola nitida'', ''Cola acuminata'' (1) ·
''Ilex paraguariensis'' (1) ·
''Ilex vomitoria'' (1) ·
''Paullinia cupana'' (1) ·
''Sophora secundiflora''. Texas mountain laurel, frijolillo (1) ·
''Theobroma cacao'' (1) ·
Deadly nightshade (1) ·
Henbane, black henbane (1) ·
Mandrake (1) ·
Nuedexta (1) ·
The ayahuasca vine, ''yagé'', ''caapi'', ''mariri'' (1) ·
Ultracet, Tramacet (1) ·
Wormwood, absinthe, la Fée Verte, the Green Muse (1)
classes: (Click arrow to add another value)
mechanism:
None (1) ·
Active alkaloid is cytisine, a nicotinic acetylcholine receptor agonist. NOT a classical 5-HT2A psychedelic. (1) ·
Active principle is thujone, a GABA-A antagonist (the opposite of most CNS depressants). Also present in cooking sage (''Salvia officinalis''), tansy, and ''Thuja'' cedars. (1) ·
Caffeine (1.5–2%) + theobromine + kolanin (a glycoside). (1) ·
Caffeine (highest of the ''Ilex'' genus) plus saponins that produce ritual vomiting at high doses. (1) ·
Caffeine (sometimes called 'mateine' historically, though chemically identical), theobromine, theophylline, plus polyphenols. (1) ·
Caffeine + theophylline + L-theanine. L-theanine (an amino acid unique to tea) modulates glutamate and produces an 'alpha-wave' calming overlay on caffeine's stimulation, hence tea's reputation as a 'cleaner' stimulant than coffee. (1) ·
Caffeine is a non-selective adenosine A1/A2A receptor antagonist; also weak PDE inhibition. Beans contain theobromine (3,7-DMX) and theophylline (1,3-DMX) in smaller amounts. (1) ·
Contains the β-carboline alkaloids harmine, harmaline, and tetrahydroharmine, reversible monoamine oxidase inhibitors (RIMAs) that allow oral DMT to reach the brain. (1) ·
Highest natural caffeine content of any plant (2–7% by dry weight, ~2–4× coffee). Caffeine is bound to tannins, producing a slower release than pure coffee caffeine. (1) ·
Primary alkaloid is theobromine (3,7-dimethylxanthine), with minor caffeine. Also contains phenethylamine, anandamide (an endogenous cannabinoid), tryptophan (serotonin precursor), and flavanols. The combined effect is mild stimulation + mood elevation. (1) ·
Tropane alkaloids: hyoscyamine (dominant; the racemic form is atropine), scopolamine. Competitive muscarinic antagonism. (1) ·
Tropane alkaloids: hyoscyamine, scopolamine, atropine, apoatropine. (1) ·
Tropane alkaloids: hyoscyamine, scopolamine, in higher seed concentrations than belladonna or datura. (1) ·
Tropane alkaloids: scopolamine (dominant), hyoscyamine, atropine. Competitive antagonism at muscarinic acetylcholine receptors. (1) ·
'"`UNIQ--vote-00001580-QINU`"' First FDA-approved treatment for PBA. The 10 mg quinidine daily dose is far below antiarrhythmic levels but sufficient to nearly fully inhibit CYP2D6, the basis of the combination's pharmacokinetic rationale'"`UNIQ--ref-00001581-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000006-QINU`"' (2) ·
'"`UNIQ--vote-00000008-QINU`"', '"`UNIQ--vote-00000009-QINU`"' (5) ·
'"`UNIQ--vote-00000065-QINU`"' (1) ·
'"`UNIQ--vote-000000AD-QINU`"', '"`UNIQ--vote-000000AE-QINU`"' (1) ·
'"`UNIQ--vote-000000CF-QINU`"', '"`UNIQ--vote-000000D0-QINU`"', '"`UNIQ--vote-000000D1-QINU`"' (1) ·
'"`UNIQ--vote-000003A0-QINU`"', '"`UNIQ--vote-000003A1-QINU`"' (1) ·
'"`UNIQ--vote-0000069B-QINU`"', '"`UNIQ--vote-0000069C-QINU`"' (1) ·
'"`UNIQ--vote-00000747-QINU`"', '"`UNIQ--vote-00000748-QINU`"' (1) ·
'"`UNIQ--vote-0000081E-QINU`"' (1) ·
'"`UNIQ--vote-0000152F-QINU`"' (1) ·
'"`UNIQ--vote-00001582-QINU`"' (1)
starting dose:
None (11) ·
1 capsule (20/10 mg dextromethorphan/quinidine) PO once daily × 7 days, then 1 capsule BID (1) ·
2 tablets (75 mg tramadol / 650 mg acetaminophen) PO every 4-6 hours as needed; maximum 8 tablets/day for ≤5 days (1) ·
A measured pour of absinthe diluted 5:1 with cold water over sugar (the louche ritual) (1) ·
One cup (~40–60 mg caffeine; about half of brewed coffee) (1) ·
One cup (~80–145 mg caffeine for brewed; 60–100 mg for instant) (1)
preparations:
20 mg dextromethorphan HBr / 10 mg quinidine sulfate capsules (1) ·
Bark/woody stem decocted with a DMT-source plant (''Psychotria viridis'', ''Diplopterys cabrerana'') to make ayahuasca (1) ·
Bright red seeds, traditionally ingested or smoked. Highly toxic, narrow margin between active and lethal (1) ·
Dried leaves and twigs, infused in a gourd (''mate'') and drunk through a metal straw (''bombilla'') (1) ·
Dried leaves, infused. Six major processings: white, green, yellow, oolong, black, pu-erh (1) ·
Dried leaves; absinthe liqueur (120–160 proof, with hyssop, lemon balm, fennel, anise, sometimes Acorus calamus) (1) ·
Fermented and roasted seeds, ground. Mexican tradition: drunk with chili, cornmeal, achiote. European tradition: with sugar and milk (1) ·
Flowers or leaves infused or smoked. Highly variable potency; narrow toxic margin (1) ·
Fresh nuts chewed; also dried and powdered (1) ·
Leaves and seeds, traditionally smoked or infused. Possibly the original Pythia oracle plant (1) ·
Leaves, berries, root. Historically: belladonna cigarettes ("Asthmador") OTC in US until the 1970s (1) ·
Roasted beans, ground; brewed (drip, French press, espresso, cold brew, percolated) (1) ·
Roasted seeds ground to powder, mixed with water; commercial syrups and energy drinks (1) ·
Root, traditionally carved into ''mannikens'' or infused into wine (1) ·
Toasted leaves and twigs decocted to a near-black concentrate (1) ·
Tramadol/acetaminophen 37.5/325 mg tablets (1)
fda max:
routes: (Click arrow to add another value)
onset:
duration:
halflife:
None (12) ·
Dextromethorphan substantially prolonged by quinidine's CYP2D6 inhibition (typical extensive metabolizers see ~10× higher AUC); quinidine ~6-8 hours'"`UNIQ--ref-00001583-QINU`"' (1) ·
Tramadol ~5-7 hours (M1 metabolite ~9 hours); acetaminophen 1-3 hours'"`UNIQ--ref-00001530-QINU`"' (1) ·
~5 h (caffeine) (2)
bioavailability:
pregnancy:
None (13) ·
Avoid; neonatal opioid withdrawal documented.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1) ·
Limit to <200 mg/d (~2 cups brewed) (1) ·
Limited data; quinidine has been used in pregnancy as antiarrhythmic.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)
legal:
None (11) ·
Currently legal in most jurisdictions with thujone limits (1) ·
Plant unrestricted; pharmaceutical atropine Rx-only (1) ·
Unrestricted (food) (1) ·
[[USLegal:Prescription only|Rx-only]] in US. Caution with QT-prolonging medicines (quinidine itself is class IA antiarrhythmic, and the dose here, though sub-antiarrhythmic, still contributes to QT)'"`UNIQ--ref-00001585-QINU`"' (1) ·
[[USLegal:Schedule IV|Schedule IV controlled substance]] in US (tramadol was reclassified from non-controlled to Schedule IV in 2014 after recognition of dependence risk) (1)
Showing below up to 16 results in range #1 to #16.