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Medicines (732)

Medicines > classes

: Rhapsodica

or Sedative-Hypnotic

& routes: Oral

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Artemisia absinthium (1) · Bromazolam (1)

(none, never marketed) (1) · Wormwood, absinthe, la Fée Verte, the Green Muse (1)

Active principle is thujone, a GABA-A antagonist (the opposite of most CNS depressants). Also present in cooking sage (''Salvia officinalis''), tansy, and ''Thuja'' cedars. (1) · Positive allosteric modulator of the GABA<sub>A</sub> receptor at the benzodiazepine binding site; increases frequency of Cl<sup>−</sup> channel opening, producing anxiolytic, sedative, hypnotic, anticonvulsant, and skeletal-muscle relaxant effects. (1)

No approved medical problem. Encountered as a designer/research benzodiazepine and, increasingly, as an adulterant in illicit opioid supplies. (1) · '"`UNIQ--vote-00000008-QINU`"', '"`UNIQ--vote-00000009-QINU`"' (1)

A measured pour of absinthe diluted 5:1 with cold water over sugar (the louche ritual) (1) · No medical dose. Active recreational doses reported in the 0.5–1.5 mg range (similar potency to alprazolam). (1)

Dried leaves; absinthe liqueur (120–160 proof, with hyssop, lemon balm, fennel, anise, sometimes Acorus calamus) (1) · Illicit tablets ("bars"), powders, blotter, occasionally solutions. No pharmaceutical product exists. (1)

None (1) · N/A (never approved) (1)

None (1) · ~20–40 min PO; faster sublingual/intranasal. (1)

None (1) · 6–10 h subjective; full pharmacologic effect considerably longer. (1)

None (1) · Estimated ~12–17 h (some sources cite up to ~21 h); active metabolites prolong effect. (1)

None (1) · Not formally characterized in humans. (1)

None (1) · Avoid. Benzodiazepines are associated with neonatal sedation, floppy-infant syndrome, and withdrawal; teratogenic signal weak but non-zero. Designer benzo with no safety data, assume worst-case. (1)

None (1) · Currently legal in most jurisdictions with thujone limits (1)

Showing below up to 2 results in range #1 to #2.

A

Artemisia absinthium

B

Bromazolam

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