Jump to content

Drilldown: Medicines

Nav

Choose a table:

Medicines (732)

Medicines > classes

: Sedative-Hypnotic

or [[:Category:Analgesics|Non-opioid analgesic]]

& routes: Oral

Use the filters below to narrow your results.

Acetaminophen (paracetamol, APAP) (1) · Bromazolam (1)

(none, never marketed) (1) · Tylenol, Panadol (international), Ofirmev (IV); huge OTC presence (1)

None (1) · Positive allosteric modulator of the GABA<sub>A</sub> receptor at the benzodiazepine binding site; increases frequency of Cl<sup>−</sup> channel opening, producing anxiolytic, sedative, hypnotic, anticonvulsant, and skeletal-muscle relaxant effects. (1)

No approved medical problem. Encountered as a designer/research benzodiazepine and, increasingly, as an adulterant in illicit opioid supplies. (1) · '"`UNIQ--vote-000006A2-QINU`"', '"`UNIQ--vote-000006A3-QINU`"', '"`UNIQ--vote-000006A4-QINU`"' (1)

325-1000 mg PO every 4-6 hours as needed; maximum 4 g/d in healthy adults, 3 g/d in regular users or hepatic risk; pediatric 10-15 mg/kg every 4-6 hours (1) · No medical dose. Active recreational doses reported in the 0.5–1.5 mg range (similar potency to alprazolam). (1)

325, 500, 650 mg tablets; 80, 160 mg chewables; 160 mg/5 mL pediatric liquid; 325 mg suppository; 1000 mg/100 mL IV (Ofirmev); fixed-dose combinations with opioids, decongestants, antihistamines (1) · Illicit tablets ("bars"), powders, blotter, occasionally solutions. No pharmaceutical product exists. (1)

4 g/d in healthy adults; 3 g/d conservative limit; 2 g/d in cirrhosis or chronic alcohol use (1) · N/A (never approved) (1)

PO: 30-60 minutes; IV: minutes (1) · ~20–40 min PO; faster sublingual/intranasal. (1)

4-6 hours (1) · 6–10 h subjective; full pharmacologic effect considerably longer. (1)

1-3 hours (normal liver); markedly prolonged in overdose with glutathione depletion'"`UNIQ--ref-000006A5-QINU`"' (1) · Estimated ~12–17 h (some sources cite up to ~21 h); active metabolites prolong effect. (1)

Not formally characterized in humans. (1) · ~85-98% (oral)'"`UNIQ--ref-000006A6-QINU`"' (1)

Avoid. Benzodiazepines are associated with neonatal sedation, floppy-infant syndrome, and withdrawal; teratogenic signal weak but non-zero. Designer benzo with no safety data, assume worst-case. (1) · Long the preferred analgesic-antipyretic in pregnancy; recent observational studies have raised speculative neurodevelopmental signals that remain under investigation.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)

None (1) · OTC and [[USLegal:Prescription only|Rx-only]] (IV, combination products) in US (1)

Showing below up to 2 results in range #1 to #2.

A

Acetaminophen

B

Bromazolam

Retrieved from "https://pharmacopedia.wiki/p/Special:Drilldown/Medicines"