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Medicines (732)

Medicines > classes

: Sedative-Hypnotic

or [[:Category:Antihistamines|First-generation antihistamine (piperazine)]]

& routes: oral

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Bromazolam (1) · Meclizine (1)

(none, never marketed) (1) · Antivert (Rx), Bonine (OTC), Dramamine Less Drowsy (OTC) (1)

Positive allosteric modulator of the GABA<sub>A</sub> receptor at the benzodiazepine binding site; increases frequency of Cl<sup>−</sup> channel opening, producing anxiolytic, sedative, hypnotic, anticonvulsant, and skeletal-muscle relaxant effects. (1) · '"`UNIQ--vote-00000013-QINU`"' Anticholinergic burden (dry mouth, blurred vision, urinary retention, cognitive effects) is the principal adverse-event concern and the basis for Beers-list cautions in elderly patients'"`UNIQ--ref-00000014-QINU`"'. (1)

No approved medical problem. Encountered as a designer/research benzodiazepine and, increasingly, as an adulterant in illicit opioid supplies. (1) · '"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"', '"`UNIQ--vote-00000017-QINU`"' (1)

Motion sickness: 25-50 mg PO 1 hour before travel, repeat every 24 hours as needed. Vertigo: 25-100 mg/day divided (1) · No medical dose. Active recreational doses reported in the 0.5–1.5 mg range (similar potency to alprazolam). (1)

Illicit tablets ("bars"), powders, blotter, occasionally solutions. No pharmaceutical product exists. (1) · Tablets 12.5, 25 mg; chewable tablets 25 mg (1)

100 mg/day (vertigo) (1) · N/A (never approved) (1)

~1 hour (1) · ~20–40 min PO; faster sublingual/intranasal. (1)

12-24 hours (long for an antihistamine) (1) · 6–10 h subjective; full pharmacologic effect considerably longer. (1)

Estimated ~12–17 h (some sources cite up to ~21 h); active metabolites prolong effect. (1) · ~6 hours'"`UNIQ--ref-00000018-QINU`"' (1)

Not formally characterized in humans. (1) · ~25% (oral)'"`UNIQ--ref-00000019-QINU`"' (1)

Avoid. Benzodiazepines are associated with neonatal sedation, floppy-infant syndrome, and withdrawal; teratogenic signal weak but non-zero. Designer benzo with no safety data, assume worst-case. (1) · Older agent with substantial use experience; observational signals reassuring for first-trimester exposure.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)

None (1) · [[USLegal:Over-the-counter|OTC]] as Bonine and Dramamine Less Drowsy; [[USLegal:Prescription only|Rx-only]] as Antivert (1)

Showing below up to 2 results in range #1 to #2.

B

Bromazolam

M

Meclizine

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