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Medicines (732)

Medicines > classes

: Sedative-hypnotic

or [[:Category:Orexigenics|Appetite-promoting medicine (orexigenic)]]

& routes: Oral

Use the filters below to narrow your results.

Bromazolam (1) · Cyproheptadine (hydrochloride) (1)

(none, never marketed) (1) · Periactin (US brand discontinued; generic widely available) (1)

Positive allosteric modulator of the GABA<sub>A</sub> receptor at the benzodiazepine binding site; increases frequency of Cl<sup>−</sup> channel opening, producing anxiolytic, sedative, hypnotic, anticonvulsant, and skeletal-muscle relaxant effects. (1) · '"`UNIQ--vote-00000017-QINU`"' Anticholinergic and sedating, with the standard first-generation antihistamine Beers-list concerns in elderly patients'"`UNIQ--ref-00000018-QINU`"'. (1)

No approved medical problem. Encountered as a designer/research benzodiazepine and, increasingly, as an adulterant in illicit opioid supplies. (1) · '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"', '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"', '"`UNIQ--vote-0000001D-QINU`"' (1)

Allergy: 4 mg PO TID. Serotonin syndrome: 12 mg loading dose PO or by nasogastric tube, then 2 mg every 2 hours until clinical improvement. Appetite stimulation: 2-4 mg PO TID-QID (1) · No medical dose. Active recreational doses reported in the 0.5–1.5 mg range (similar potency to alprazolam). (1)

Illicit tablets ("bars"), powders, blotter, occasionally solutions. No pharmaceutical product exists. (1) · Tablets 4 mg; oral syrup 2 mg/5 mL (1)

32 mg/day adult; weight-based pediatric ceiling (1) · N/A (never approved) (1)

30-60 minutes (1) · ~20–40 min PO; faster sublingual/intranasal. (1)

6-8 hours (1) · 6–10 h subjective; full pharmacologic effect considerably longer. (1)

8-16 hours'"`UNIQ--ref-0000001E-QINU`"' (1) · Estimated ~12–17 h (some sources cite up to ~21 h); active metabolites prolong effect. (1)

Not formally characterized in humans. (1) · ~95% (oral)'"`UNIQ--ref-0000001F-QINU`"' (1)

Avoid. Benzodiazepines are associated with neonatal sedation, floppy-infant syndrome, and withdrawal; teratogenic signal weak but non-zero. Designer benzo with no safety data, assume worst-case. (1) · Limited human data; older agent with substantial use experience.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)

None (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

Showing below up to 2 results in range #1 to #2.

B

Bromazolam

C

Cyproheptadine

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