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Drilldown: Medicines

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Medicines > classes : Sedative-hypnotic or Stimulant or [[:Category:Androgen_modulators|Androgen modulator]]

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generic:
brand:
None (51) · (none, never marketed) (1) · Avodart; combined with tamsulosin as Jalyn (1) · Benzedrex (1) · Dalmane (1) · Doral (1) · Doriden (1) · Halcion (1) · Hetlioz (1) · Imovane (1) · Lunesta (1) · Mogadon (1) · Nembutal (1) · Placidyl (1) · Proscar (5 mg, BPH), Propecia (1 mg, alopecia) (1) · ProSom (1) · Quaalude (1) · Restoril (1) · Rohypnol (1) · Rozerem (1) · Seconal (1) · Sonata (1) · THIP (1) · Versed (1) · Xyrem (1)
classes: (Click arrow to add another value)
mechanism:
GABAA positive allosteric modulator (15) · Monoamine releasing agent (8) · Dopamine/norepinephrine reuptake inhibitor (5) · None (4) · GABAA positive allosteric modulator (non-benzodiazepine) (3) · Cathinone analogue; monoamine reuptake inhibitor (2) · Dopamine and norepinephrine reuptake inhibitor (2) · GABAA potentiator and direct activator (2) · Melatonin receptor agonist (2) · Norepinephrine–dopamine reuptake inhibitor (2)
uses:
None (72) · No approved medical problem. Encountered as a designer/research benzodiazepine and, increasingly, as an adulterant in illicit opioid supplies. (1) · '"`UNIQ--vote-0000052E-QINU`"', '"`UNIQ--vote-0000052F-QINU`"', '"`UNIQ--vote-00000530-QINU`"' (1) · '"`UNIQ--vote-00000D57-QINU`"', '"`UNIQ--vote-00000D58-QINU`"' (1)
starting dose:
None (72) · 0.5 mg PO once daily (1) · 5 mg PO daily for BPH; 1 mg PO daily for androgenetic alopecia (1) · No medical dose. Active recreational doses reported in the 0.5–1.5 mg range (similar potency to alprazolam). (1)
preparations:
None (72) · 0.5 mg capsules (1) · 1 mg, 5 mg tablets (1) · Illicit tablets ("bars"), powders, blotter, occasionally solutions. No pharmaceutical product exists. (1)
fda max:
None (72) · 0.5 mg/d (1) · 5 mg/d (1) · N/A (never approved) (1)
routes:
None (72) · intranasal; rectal and IV reported. (1) · Oral (3) · sublingual (1)
onset:
None (72) · BPH symptom improvement at 3-6 months; prostate volume reduction over 6-12 months; hair regrowth at 6-12 months (1) · Prostate volume reduction over 6-12 months (1) · ~20–40 min PO; faster sublingual/intranasal. (1)
duration:
None (72) · 24 hours (1) · 24 hours; tissue effects persist weeks (1) · 6–10 h subjective; full pharmacologic effect considerably longer. (1)
halflife:
None (72) · Estimated ~12–17 h (some sources cite up to ~21 h); active metabolites prolong effect. (1) · ~5 weeks (much longer than finasteride's ~6 hours)'"`UNIQ--ref-00000D59-QINU`"' (1) · ~5-6 hours in young men, ~8 hours in elderly'"`UNIQ--ref-00000531-QINU`"' (1)
bioavailability:
None (72) · Not formally characterized in humans. (1) · ~60% (oral)'"`UNIQ--ref-00000D5A-QINU`"' (1) · ~63% (oral)'"`UNIQ--ref-00000532-QINU`"' (1)
pregnancy:
None (72) · '''Pregnant individuals should not handle crushed/broken tablets''' (skin absorption risk); can cause hypospadias in male fetus. Not used in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · '''Pregnant individuals should not handle dutasteride capsules''' (skin absorption risk through intact capsule); can cause hypospadias in male fetus.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Avoid. Benzodiazepines are associated with neonatal sedation, floppy-infant syndrome, and withdrawal; teratogenic signal weak but non-zero. Designer benzo with no safety data, assume worst-case. (1)
legal:
None (73) · [[USLegal:Prescription only|Rx-only]] in US (2)

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