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Medicines > classes : Selective 5HT2A inverse agonist (with weaker 5HT2C inverse agonism) or Stimulant or Tryptamine

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generic:
brand:
None (67) · Benzedrex (1) · Nuplazid (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (15) · Monoamine releasing agent (8) · Dopamine/norepinephrine reuptake inhibitor (5) · Cathinone analogue; monoamine reuptake inhibitor (2) · Dopamine and norepinephrine reuptake inhibitor (2) · Norepinephrine–dopamine reuptake inhibitor (2)
uses:
None (68) · Hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Investigational for psychosis in other dementias and as augmentation for depression. (1)
starting dose:
None (68) · 34 mg PO once daily (1)
preparations:
None (68) · 10 mg, 34 mg capsules/tablets (1)
fda max:
None (68) · 34 mg/d (1)
routes:
None (68) · Oral (1)
onset:
None (68) · Benefit over weeks of dosing (1)
duration:
None (68) · Daily dosing (1)
halflife:
None (68) · ~57 hours (parent), ~200 h (active metabolite) (1)
bioavailability:
None (68) · Not characterized; oral dosing once daily (1)
pregnancy:
None (68) · Limited data; avoid (1)
legal:
None (68) · Rx. FDA black-box warning for increased mortality in elderly patients with dementia-related psychosis (class warning shared with all antipsychotics) (1)

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