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Medicines > classes : Stimulant or [[:Category:Antihypertensives|Antihypertensive]] & fda max: ~480 mg/d (oral); IV per protocol

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generic:
Diltiazem (1)
brand:
Cardizem, Tiazac, Cartia XT, Dilacor XR, Taztia XT, Matzim LA (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-0000063C-QINU`"' Avoid in HFrEF (negative inotropy). CYP3A4 substrate AND moderate inhibitor — interacts substantially with statins (especially simvastatin), tacrolimus, cyclosporine, and many other CYP3A4 substrates'"`UNIQ--ref-0000063D-QINU`"'. (1)
uses:
'"`UNIQ--vote-0000063E-QINU`"', '"`UNIQ--vote-0000063F-QINU`"', '"`UNIQ--vote-00000640-QINU`"', '"`UNIQ--vote-00000641-QINU`"' (1)
starting dose:
ER 180-240 mg PO once daily; IR 30 mg PO QID; IV 0.25 mg/kg over 2 min for acute rate control, then 5-15 mg/h infusion (1)
preparations:
IR 30, 60, 90, 120 mg tablets; multiple ER capsules and tablets 60-420 mg; IV 5 mg/mL (1)
fda max: (Click arrow to add another value)
routes:
IV (1) · multiple ER formulations) (1) · Oral (IR (1)
onset:
IV: 3-7 minutes (rate control); PO IR: 30-60 minutes; ER: hours (1)
duration:
IR: 4-8 hours; ER: 24 hours (1)
halflife:
3-4.5 hours (IR); 5-7 hours (ER; effective duration 24 hours via formulation)'"`UNIQ--ref-00000642-QINU`"' (1)
bioavailability:
~40% (oral; extensive first-pass via CYP3A4)'"`UNIQ--ref-00000643-QINU`"' (1)
pregnancy:
Limited data; labetalol/nifedipine generally preferred. Crosses placenta.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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