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Medicines (732)

Medicines > classes

: Tryptamine

or [[:Category:Classical Psychedelics (Serotonergic)|Serotonergic psychedelic]]

& duration: 4-6 hours

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COMP360 (Compass Pathways, investigational synthesized clinical formulation) (1)

Prodrug to [[Psilocin|psilocin]] (4-hydroxy-N,N-dimethyltryptamine), a partial agonist at the [[Receptor:5-HT2A|5-HT2A]] serotonin receptor; the action that defines the classical-psychedelic mechanism (1)

(investigational) '"`UNIQ--vote-000000EF-QINU`"', '"`UNIQ--vote-000000F0-QINU`"', '"`UNIQ--vote-000000F1-QINU`"', '"`UNIQ--vote-000000F2-QINU`"', '"`UNIQ--vote-000000F3-QINU`"' (1)

Modern clinical-trial standard: 25 mg synthesized psilocybin, single oral dose with psychological support (1)

Synthesized psilocybin capsules (COMP360 and other investigational formulations); dried whole [[Psilocybe|Psilocybe]] mushrooms (variable potency, no legal supply chain in most jurisdictions); psilocybin truffles (Psilocybe sclerotia, legal in the Netherlands) (1)

Not FDA-approved; clinical-trial protocols use up to 30 mg in adult investigational dosing (1)

Oral (1)

20-45 min subjective onset; psilocin formation from psilocybin requires intestinal and hepatic alkaline phosphatase (1)

Psilocin: ~2-3 h; psilocybin itself is a prodrug, dephosphorylated within minutes of absorption (1)

Oral bioavailability of psilocin from administered psilocybin approximately 50% (1)

Not studied in human pregnancy; no approved clinical use in any population (1)

None (1)

Showing below up to 1 result in range #1 to #1.

P

Psilocybin

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