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Medicines (732)

Medicines > classes: [[:Category:Angiotensin_receptor_blockers|Angiotensin receptor blocker (ARB)]]

& fda max

: 100 mg/d

or 4.8 g/d (IV severe infection)

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Losartan (1)

Cozaar (1)

'"`UNIQ--vote-000000B6-QINU`"' Active metabolite EXP3174 is ~10-40-fold more potent than the parent and accounts for most of the antihypertensive effect; CYP2C9 polymorphism affects conversion'"`UNIQ--ref-000000B7-QINU`"'. (1)

'"`UNIQ--vote-000000B8-QINU`"', '"`UNIQ--vote-000000B9-QINU`"', '"`UNIQ--vote-000000BA-QINU`"', '"`UNIQ--vote-000000BB-QINU`"' (1)

50 mg PO daily (25 mg in volume depletion or hepatic impairment) (1)

25 mg, 50 mg, 100 mg tablets (1)

Oral (1)

BP effect 1-2 weeks; antihypertensive peak 3-6 weeks (1)

24 hours (1)

2 hours (parent); 6-9 hours for active carboxylic acid metabolite EXP3174'"`UNIQ--ref-000000BC-QINU`"' (1)

~33% (extensive first-pass via CYP2C9 and CYP3A4)'"`UNIQ--ref-000000BD-QINU`"' (1)

'''Contraindicated in pregnancy''' (all trimesters); fetal renal injury, oligohydramnios, hypocalvaria, hypotension. Stop on detection'"`UNIQ--ref-000000BE-QINU`"' (1)

[[USLegal:Prescription only|Rx-only]] in US (1)

Showing below up to 1 result in range #1 to #1.

L

Losartan

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