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Medicines > classes: [[:Category:Antiarrhythmics|Antiarrhythmic (Vaughan-Williams class IC)]] & fda max: 400 mg/d

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generic:
Flecainide (1)
brand:
Tambocor (US brand discontinued) (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-0000113A-QINU`"' Concomitant β-blocker or CCB is required when used for AF to prevent 1:1 atrial flutter conduction (flecainide can slow atrial rate to a level where AV conduction allows dangerous ventricular rates). CYP2D6 substrate'"`UNIQ--ref-0000113B-QINU`"'. (1)
uses:
'"`UNIQ--vote-0000113C-QINU`"', '"`UNIQ--vote-0000113D-QINU`"', '"`UNIQ--vote-0000113E-QINU`"' (1)
starting dose:
50 mg PO BID; titrate to 100-200 mg BID; pill-in-pocket 200-300 mg PO single dose for AF conversion (1)
preparations:
50, 100, 150 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
AF conversion within hours of single PO dose (1)
duration:
12 hours (1)
halflife:
~14 hours (adults); longer in elderly and renal impairment'"`UNIQ--ref-0000113F-QINU`"' (1)
bioavailability:
~90% (oral)'"`UNIQ--ref-00001140-QINU`"' (1)
pregnancy:
Use in fetal SVT (transplacental antiarrhythmic therapy) is established; otherwise weigh against alternatives.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. '''Contraindicated in structural heart disease''' — CAST trial (1989) showed increased mortality from class IC agents in patients with prior MI; modern use is limited to structurally normal hearts'"`UNIQ--ref-00001141-QINU`"' (1)

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