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Medicines > classes: [[:Category:Antihistamines|Antihistamine]] & onset : 1-2 hours or Anticonvulsant effect emerges with slow titration over weeks; tremor effect over weeks

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generic:
Fexofenadine (1)
brand:
Allegra, Allegra Allergy 24 Hour, Mucinex Allergy (combo) — all now OTC in US (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-00000CC9-QINU`"' Mostly excreted unchanged in feces and urine; P-glycoprotein substrate (the basis of the fruit-juice interaction). (1)
uses:
'"`UNIQ--vote-00000CCA-QINU`"', '"`UNIQ--vote-00000CCB-QINU`"' (1)
starting dose:
60 mg PO BID or 180 mg PO once daily (1)
preparations:
30, 60, 180 mg tablets; 30 mg ODT; 6 mg/mL oral suspension; all OTC (1)
fda max:
180 mg/d (adults) (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
12-24 hours (1)
halflife:
~14 hours'"`UNIQ--ref-00000CCC-QINU`"' (1)
bioavailability:
~33% (oral; fruit juices including grapefruit, orange, and apple reduce absorption substantially via OATP1A2 inhibition — distinctive interaction not seen with most other H1s)'"`UNIQ--ref-00000CCD-QINU`"' (1)
pregnancy:
Generally considered safe; loratadine and cetirizine have more pregnancy data and are typically preferred.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1)

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