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Medicines > classes: [[:Category:Antihyperglycemic_agents|Antihyperglycemic agent]] & fda max : 5 mg/d or 8 mg/d

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generic:
Glimepiride (1) · Linagliptin (1)
brand:
Amaryl (1) · Tradjenta; with metformin Jentadueto (1)
classes: (Click arrow to add another value)
mechanism:
None (2)
uses:
'"`UNIQ--vote-00000491-QINU`"' (1) · '"`UNIQ--vote-0000117B-QINU`"' (1)
starting dose:
1-2 mg PO once daily with breakfast; titrate by glycemic response (1) · 5 mg PO once daily (no renal dose adjustment, unlike sitagliptin) (1)
preparations:
1 mg, 2 mg, 4 mg tablets (1) · 5 mg tablets; combination with metformin (1)
fda max: (Click arrow to add another value)
routes:
Oral (2)
onset:
1-2 hours (1) · Postprandial glucose effect within days; HbA1c by 12 weeks (1)
duration:
24 hours (2)
halflife:
~12 hours (effective); terminal much longer'"`UNIQ--ref-0000117C-QINU`"' (1) · ~5-9 hours (parent and active metabolites combined)'"`UNIQ--ref-00000492-QINU`"' (1)
bioavailability:
~100% (oral; not significantly affected by food)'"`UNIQ--ref-00000493-QINU`"' (1) · ~30% (oral)'"`UNIQ--ref-0000117D-QINU`"' (1)
pregnancy:
Avoid; switch to insulin. Neonatal hypoglycemia reported.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Limited data; switch to insulin where feasible.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (2)

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