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Medicines > classes: [[:Category:Antihypertensives|Antihypertensive]] & fda max: 300 mg/d & onset: BP effect within 1-2 weeks

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generic:
Irbesartan (1)
brand:
Avapro (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-0000083E-QINU`"' CYP2C9 substrate; no clinically active metabolites. The IDNT trial established renoprotection in diabetic nephropathy independent of BP lowering, contributing to the ARB class indication in T2DM with proteinuria'"`UNIQ--ref-0000083F-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000840-QINU`"', '"`UNIQ--vote-00000841-QINU`"' (1)
starting dose:
150 mg PO once daily; titrate to 300 mg if needed (1)
preparations:
75, 150, 300 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
24 hours (1)
halflife:
11-15 hours'"`UNIQ--ref-00000842-QINU`"' (1)
bioavailability:
60-80% (oral; not significantly affected by food)'"`UNIQ--ref-00000843-QINU`"' (1)
pregnancy:
'''Contraindicated in pregnancy''' (all trimesters); fetal renal injury, oligohydramnios, hypocalvaria, hypotension. Stop on detection'"`UNIQ--ref-00000844-QINU`"' (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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