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Medicines > classes: [[:Category:Antimuscarinics|Antimuscarinic (M3-selective)]] & routes : Oral or rectal

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generic:
Solifenacin (1)
brand:
Vesicare (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-00000DFA-QINU`"' CYP3A4 substrate; QT-interval prolongation has been reported at higher doses. Like other antimuscarinics, contributes to cumulative anticholinergic burden in older adults'"`UNIQ--ref-00000DFB-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000DFC-QINU`"', '"`UNIQ--vote-00000DFD-QINU`"' (1)
starting dose:
5 mg PO once daily; titrate to 10 mg after 2 weeks if needed (1)
preparations:
5, 10 mg tablets (1)
fda max:
10 mg/d (5 mg if severe renal or moderate hepatic impairment, or strong CYP3A4 inhibitors) (1)
routes: (Click arrow to add another value)
onset:
Symptom improvement within 1-2 weeks (1)
duration:
24 hours (1)
halflife:
~45-68 hours'"`UNIQ--ref-00000DFE-QINU`"' (1)
bioavailability:
~90% (oral)'"`UNIQ--ref-00000DFF-QINU`"' (1)
pregnancy:
Limited data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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