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Medicines > classes: [[:Category:Atypical neuroleptics|Atypical neuroleptic (second-generation)]] & fda max: 20 mg/day (oral)

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generic:
Olanzapine (1)
brand:
Zyprexa (oral, IM acute), Zyprexa Zydis (ODT), Zyprexa Relprevv (LAI), Lybalvi (with samidorphan) (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' (1)
starting dose:
Schizophrenia / acute mania: 5-10 mg PO once daily, target 10-15 mg/day. Acute agitation IM: 10 mg, may repeat in 2 hours. Relprevv LAI: 150-300 mg every 4 weeks after oral overlap (1)
preparations:
Tablets 2.5, 5, 7.5, 10, 15, 20 mg; ODT (Zydis) 5, 10, 15, 20 mg; acute IM injection 10 mg/vial; Relprevv LAI 210, 300, 405 mg vials (1)
fda max: (Click arrow to add another value)
routes:
intramuscular (acute and long-acting) (1) · Oral (1)
onset:
Sedation from first dose; neuroleptic effect emerges over days to weeks (1)
duration:
24 hours (oral); 2-4 weeks (LAI) (1)
halflife:
21-54 hours'"`UNIQ--ref-00000026-QINU`"' (1)
bioavailability:
~60% (oral); ~100% (IM)'"`UNIQ--ref-00000027-QINU`"' (1)
pregnancy:
Signal for gestational diabetes and metabolic syndrome with maternal exposure; the metabolic load can be substantial during pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1)

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