Jump to content

Drilldown: Medicines

Pharmacopedia
BrowseCategoriesLog in

Choose a table:


Medicines > classes: [[:Category:Cardiovascular_agents|Cardiovascular agent]] & fda max: Oral maintenance 400 mg/d typical; higher in refractory cases

Use the filters below to narrow your results.

generic:
Amiodarone (1)
brand:
Cordarone, Pacerone, Nexterone (IV) (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000CB0-QINU`"', '"`UNIQ--vote-00000CB1-QINU`"', '"`UNIQ--vote-00000CB2-QINU`"' (1)
starting dose:
Oral load 800-1600 mg/d in divided doses for 1-3 weeks, then 600-800 mg/d for 1 month, then 200-400 mg/d maintenance; IV 150 mg over 10 min then 1 mg/min for 6 hours then 0.5 mg/min (1)
preparations:
100, 200, 400 mg tablets; 50 mg/mL IV (with polysorbate 80 in older formulations causing hypotension); 1.5 mg/mL Nexterone IV (PVC-free, lower hypotension risk) (1)
fda max: (Click arrow to add another value)
routes:
IV (1) · Oral (1)
onset:
IV: minutes; oral: weeks to load (1)
duration:
Weeks after discontinuation (extremely long half-life) (1)
halflife:
~58 days (parent); ~61 days (desethylamiodarone, active metabolite)'"`UNIQ--ref-00000CB3-QINU`"' (1)
bioavailability:
~50% (oral; highly variable)'"`UNIQ--ref-00000CB4-QINU`"' (1)
pregnancy:
Generally avoided; fetal goiter/hypothyroidism risk (iodine load). Used only for life-threatening arrhythmia.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries '''Boxed Warnings''' for pulmonary toxicity (interstitial pneumonitis, fibrosis), hepatotoxicity, and proarrhythmia'"`UNIQ--ref-00000CB5-QINU`"' (1)

Showing below up to 1 result in range #1 to #1.

View (previous 250 | next 250) (20 | 50 | 100 | 250 | 500)


View (previous 250 | next 250) (20 | 50 | 100 | 250 | 500)

Retrieved from "https://pharmacopedia.wiki/p/Special:Drilldown/Medicines"