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Drilldown: Medicines

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Medicines (732)

Medicines > generic: Amiodarone

& classes: [[:Category:Cardiovascular_agents|Cardiovascular agent]]

& routes: IV

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Cordarone, Pacerone, Nexterone (IV) (1)

None (1)

'"`UNIQ--vote-00000CB0-QINU`"', '"`UNIQ--vote-00000CB1-QINU`"', '"`UNIQ--vote-00000CB2-QINU`"' (1)

Oral load 800-1600 mg/d in divided doses for 1-3 weeks, then 600-800 mg/d for 1 month, then 200-400 mg/d maintenance; IV 150 mg over 10 min then 1 mg/min for 6 hours then 0.5 mg/min (1)

100, 200, 400 mg tablets; 50 mg/mL IV (with polysorbate 80 in older formulations causing hypotension); 1.5 mg/mL Nexterone IV (PVC-free, lower hypotension risk) (1)

Oral maintenance 400 mg/d typical; higher in refractory cases (1)

IV: minutes; oral: weeks to load (1)

Weeks after discontinuation (extremely long half-life) (1)

~58 days (parent); ~61 days (desethylamiodarone, active metabolite)'"`UNIQ--ref-00000CB3-QINU`"' (1)

~50% (oral; highly variable)'"`UNIQ--ref-00000CB4-QINU`"' (1)

Generally avoided; fetal goiter/hypothyroidism risk (iodine load). Used only for life-threatening arrhythmia.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)

[[USLegal:Prescription only|Rx-only]] in US. Carries '''Boxed Warnings''' for pulmonary toxicity (interstitial pneumonitis, fibrosis), hepatotoxicity, and proarrhythmia'"`UNIQ--ref-00000CB5-QINU`"' (1)

Showing below up to 1 result in range #1 to #1.

A

Amiodarone

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