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Medicines > classes: [[:Category:Dopamine agonists|Dopamine D2/D3 receptor agonist (non-ergot)]] & duration: TID dosing (IR); once-daily (ER)

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generic:
Pramipexole (1)
brand:
Mirapex (IR), Mirapex ER (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000017-QINU`"', '"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"' (1)
starting dose:
Parkinson disease: 0.125 mg PO TID, titrate weekly to maintenance ~1.5 mg TID. Restless legs syndrome: 0.125 mg PO 2-3 hours before bedtime, titrate to 0.5 mg/day if needed (1)
preparations:
IR tablets 0.125, 0.25, 0.5, 0.75, 1, 1.5 mg; ER tablets 0.375, 0.75, 1.5, 2.25, 3, 3.75, 4.5 mg (1)
fda max:
4.5 mg/day (Parkinson disease); 0.5 mg/day (restless legs syndrome) (1)
routes:
Oral (1)
onset:
Motor improvement over days at therapeutic dose (1)
duration: (Click arrow to add another value)
halflife:
8-12 hours (longer in elderly and renal impairment)'"`UNIQ--ref-0000001B-QINU`"' (1)
bioavailability:
>90% (oral)'"`UNIQ--ref-0000001C-QINU`"' (1)
pregnancy:
Limited human data; rarely indicated in pregnancy given the typical patient population.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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