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Medicines > classes: [[:Category:Fat-soluble_vitamins|Fat-soluble vitamin]] & onset: Days to weeks for tissue saturation

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generic:
Vitamin E (α-tocopherol; mixed natural and synthetic forms) (1)
brand:
Generic; many OTC formulations (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-000012CE-QINU`"', '"`UNIQ--vote-000012CF-QINU`"', '"`UNIQ--vote-000012D0-QINU`"' (1)
starting dose:
Replacement: 15-30 mg (22.5-45 IU) daily; NASH: 800 IU daily; AREDS-2: 400 IU daily (in combination formula) (1)
preparations:
100, 200, 400 IU softgels and capsules; many proprietary OTC blends; combined formulations (AREDS-2) (1)
fda max:
UL 1000 mg (~1500 IU natural)/d in adults; routinely exceeded in older AREDS-1 trials (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
Weeks (fat-soluble) (1)
halflife:
~3-4 days plasma; adipose tissue stores last months (1)
bioavailability:
High with fat-containing meal; reduced in malabsorption (1)
pregnancy:
Safe at replacement doses; high-dose use generally avoided.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1)

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