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Medicines > classes: [[:Category:Fixed-dose_combinations|Fixed-dose combination]] & onset: 10-30 minutes

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generic:
Oxycodone / Acetaminophen (1)
brand:
Percocet, Endocet, Roxicet, Tylox, Primlev (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-000014DD-QINU`"' The combination is the most-prescribed opioid analgesic in the US for moderate-to-severe acute pain. CPIC PGx guidance addresses CYP2D6-driven exposure variation'"`UNIQ--ref-000014DE-QINU`"'. (1)
uses:
'"`UNIQ--vote-000014DF-QINU`"', '"`UNIQ--vote-000014E0-QINU`"', '"`UNIQ--vote-000014E1-QINU`"' (1)
starting dose:
5 mg / 325 mg PO every 4-6 hours as needed; total acetaminophen <3 g/d (1)
preparations:
Oxycodone/acetaminophen 2.5/325, 5/325, 7.5/325, 10/325 mg tablets; 5/325 mg/5 mL solution (1)
fda max:
Acetaminophen 4 g/d absolute (3 g/d conservative); oxycodone titrated to effect (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
4-6 hours (1)
halflife:
Oxycodone 3-5 hours; acetaminophen 1-3 hours'"`UNIQ--ref-000014E2-QINU`"' (1)
bioavailability:
~60-87% oxycodone (high and predictable, less CYP-genotype-dependent than codeine or hydrocodone); 85-98% acetaminophen'"`UNIQ--ref-000014E3-QINU`"' (1)
pregnancy:
Limited use in pregnancy; chronic third-trimester opioid exposure produces neonatal opioid withdrawal syndrome and respiratory depression at delivery.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Schedule II|Schedule II controlled substance]] in US. Acetaminophen content limited to ≤325 mg per dosage unit (FDA 2014) (1)

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