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Medicines > classes: [[:Category:Glucocorticoids|Glucocorticoid]] & onset: Hours to days for inflammation; substantial improvement within 1 week

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generic:
Clobetasol propionate (1)
brand:
Temovate, Clobex, Cormax, Olux, Olux-E, Impoyz (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000079C-QINU`"', '"`UNIQ--vote-0000079D-QINU`"' (1)
starting dose:
Apply a thin film to affected area BID; '''limit to 2 weeks''' continuous use and ≤50 g/week (cream/ointment); ≤50 mL/week (foam/solution); avoid face, intertriginous areas (1)
preparations:
Cream, ointment, lotion, foam, solution, shampoo, spray at 0.025-0.05%; emollient and non-emollient bases (1)
fda max:
50 g/week (cream/ointment); 2-week continuous limit; 4-week maximum cumulative (1)
routes:
Topical (1)
onset: (Click arrow to add another value)
duration:
Hours to days per application (1)
halflife:
Not meaningfully described for topical use (systemic exposure varies with surface area, occlusion, skin integrity)'"`UNIQ--ref-0000079E-QINU`"' (1)
bioavailability:
Topical with variable systemic absorption depending on body site, occlusion, and skin integrity; HPA-axis suppression is documented even with brief courses to large areas'"`UNIQ--ref-0000079F-QINU`"' (1)
pregnancy:
Topical corticosteroids in pregnancy: use lowest potency and smallest area; super-potent agents like clobetasol are reserved for compelling indications.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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