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Medicines > classes: [[:Category:Guanylate_cyclase_C_agonists|Guanylate cyclase-C agonist]] & fda max: 290 mcg/d

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generic:
Linaclotide (1)
brand:
Linzess (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-00001197-QINU`"' Extracellular cGMP separately activates submucosal sensory afferents in a way that reduces visceral pain perception, distinguishing linaclotide from purely osmotic laxatives in IBS-C. Diarrhea is the dose-limiting effect'"`UNIQ--ref-00001198-QINU`"'. (1)
uses:
'"`UNIQ--vote-00001199-QINU`"', '"`UNIQ--vote-0000119A-QINU`"', '"`UNIQ--vote-0000119B-QINU`"' (1)
starting dose:
145 mcg PO once daily for chronic idiopathic constipation; 290 mcg daily for IBS-C; pediatric 72 mcg daily (1)
preparations:
72, 145, 290 mcg capsules (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Bowel movement within 1 week; abdominal pain improvement over weeks (1)
duration:
24 hours (1)
halflife:
Not meaningfully described (negligible systemic absorption — the drug acts locally and is degraded in the GI tract)'"`UNIQ--ref-0000119C-QINU`"' (1)
bioavailability:
Negligible systemic absorption'"`UNIQ--ref-0000119D-QINU`"' (1)
pregnancy:
Limited data; minimal systemic absorption likely renders fetal risk low.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' contraindicating use in children <2 years (lethal dehydration in animal studies)'"`UNIQ--ref-0000119E-QINU`"' (1)

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