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Drilldown: Medicines

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Medicines (732)

Medicines > generic: Linaclotide

& classes: [[:Category:IBS_treatments|IBS-C treatment]]

& fda max: 290 mcg/d

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Linzess (1)

'"`UNIQ--vote-00001197-QINU`"' Extracellular cGMP separately activates submucosal sensory afferents in a way that reduces visceral pain perception, distinguishing linaclotide from purely osmotic laxatives in IBS-C. Diarrhea is the dose-limiting effect'"`UNIQ--ref-00001198-QINU`"'. (1)

'"`UNIQ--vote-00001199-QINU`"', '"`UNIQ--vote-0000119A-QINU`"', '"`UNIQ--vote-0000119B-QINU`"' (1)

145 mcg PO once daily for chronic idiopathic constipation; 290 mcg daily for IBS-C; pediatric 72 mcg daily (1)

72, 145, 290 mcg capsules (1)

Oral (1)

Bowel movement within 1 week; abdominal pain improvement over weeks (1)

24 hours (1)

Not meaningfully described (negligible systemic absorption — the drug acts locally and is degraded in the GI tract)'"`UNIQ--ref-0000119C-QINU`"' (1)

Negligible systemic absorption'"`UNIQ--ref-0000119D-QINU`"' (1)

Limited data; minimal systemic absorption likely renders fetal risk low.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)

[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' contraindicating use in children <2 years (lethal dehydration in animal studies)'"`UNIQ--ref-0000119E-QINU`"' (1)

Showing below up to 1 result in range #1 to #1.

L

Linaclotide

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