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Medicines > classes: [[:Category:Incretin_modulators|Incretin pathway modulator]] & duration : 24 hours or Continuous daily dosing

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generic:
Linagliptin (1) · Sitagliptin (1)
brand:
Januvia; with metformin Janumet/Janumet XR (1) · Tradjenta; with metformin Jentadueto (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · '"`UNIQ--vote-00000762-QINU`"' Largely renally cleared, hence the eGFR-tiered dosing. Rare but well-documented signals: acute pancreatitis (uncertain causal contribution), severe joint pain, and bullous pemphigoid (class effect, especially in older Asian patients)'"`UNIQ--ref-00000763-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000764-QINU`"' (1) · '"`UNIQ--vote-0000117B-QINU`"' (1)
starting dose:
100 mg PO once daily (50 mg if CrCl 30-44; 25 mg if <30 or dialysis) (1) · 5 mg PO once daily (no renal dose adjustment, unlike sitagliptin) (1)
preparations:
25, 50, 100 mg tablets; combination tablets with metformin (1) · 5 mg tablets; combination with metformin (1)
fda max:
100 mg/d (1) · 5 mg/d (1)
routes:
Oral (2)
onset:
Postprandial glucose effect within days; HbA1c by 12 weeks (2)
duration: (Click arrow to add another value)
halflife:
~12 hours (effective); terminal much longer'"`UNIQ--ref-0000117C-QINU`"' (1) · ~12.4 hours'"`UNIQ--ref-00000765-QINU`"' (1)
bioavailability:
~30% (oral)'"`UNIQ--ref-0000117D-QINU`"' (1) · ~87% (oral)'"`UNIQ--ref-00000766-QINU`"' (1)
pregnancy:
Limited data; switch to insulin where feasible.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (2)
legal:
[[USLegal:Prescription only|Rx-only]] in US (2)

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