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Medicines > classes: [[:Category:Insulins|Insulin]] & duration: >42 hours per dose (effectively flat once at steady state)

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generic:
Insulin degludec (1)
brand:
Tresiba (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-00001356-QINU`"' Binds the same insulin receptor as endogenous insulin with comparable mitogenic-to-metabolic ratio'"`UNIQ--ref-00001357-QINU`"'. (1)
uses:
'"`UNIQ--vote-00001358-QINU`"', '"`UNIQ--vote-00001359-QINU`"' (1)
starting dose:
~10 units SC at the same time daily, or 0.1-0.2 units/kg/d; titrate by fasting glucose (1)
preparations:
100 U/mL (FlexTouch pen) and 200 U/mL (FlexTouch pen, higher-dose convenience) (1)
fda max:
Titrated to glucose; no fixed ceiling (1)
routes:
Subcutaneous (never IV; not for use in insulin pumps) (1)
onset:
~1 hour (1)
duration: (Click arrow to add another value)
halflife:
~25 hours apparent (functional duration well over 42 hours from multi-hexamer depot)'"`UNIQ--ref-0000135A-QINU`"' (1)
bioavailability:
~100% from subcutaneous depot (1)
pregnancy:
Insulin is the preferred glucose-lowering therapy in pregnancy; degludec has reassuring observational data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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