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Medicines > classes: [[:Category:Lipid-lowering_agents|Lipid-lowering agent]] & onset: Lipid changes 4-8 weeks

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generic:
Niacin (nicotinic acid, vitamin B3) (1)
brand:
Niaspan (ER, Rx), Niacor (IR, Rx); huge OTC presence (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00001035-QINU`"', '"`UNIQ--vote-00001036-QINU`"', '"`UNIQ--vote-00001037-QINU`"' (1)
starting dose:
Niaspan ER 500 mg PO at bedtime, titrate weekly to 1-2 g/d; flushing-protective aspirin 30-60 minutes before dose; pellagra replacement 100-500 mg/d (1)
preparations:
OTC IR niacin 50-500 mg tablets; Niaspan ER 500, 750, 1000 mg tablets; "no-flush" niacin (inositol hexaniacinate, lacks evidence) (1)
fda max:
2 g/d (Niaspan); higher off-label use historical (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
24 hours (1)
halflife:
~1 hour (IR niacin); ER formulations extend functional duration'"`UNIQ--ref-00001038-QINU`"' (1)
bioavailability:
High (oral; food enhances)'"`UNIQ--ref-00001039-QINU`"' (1)
pregnancy:
Pharmacologic doses generally avoided in pregnancy; vitamin doses fine.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC (low-dose, dietary supplement) and [[USLegal:Prescription only|Rx-only]] (Niaspan ER) in US (1)

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