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Medicines > classes: [[:Category:NRIs|Selective norepinephrine reuptake inhibitor (NRI)]] & fda max : 10 mg/d (adults) or 100 mg/day (adult); 1.4 mg/kg/day or 100 mg total (pediatric, whichever lower)

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generic:
Atomoxetine (1)
brand:
Strattera (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000013-QINU`"' (1)
starting dose:
Children ≤70 kg: 0.5 mg/kg/day, titrate to 1.2 mg/kg/day after 3 days. Adults and children >70 kg: 40 mg PO once daily for 3 days, then 80 mg/day, then if needed 100 mg/day after 2-4 weeks (1)
preparations:
Capsules 10, 18, 25, 40, 60, 80, 100 mg (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
ADHD effect emerges over 1-2 weeks (slower than psychostimulants); full effect 4-6 weeks (1)
duration:
24 hours (once-daily or split BID dosing) (1)
halflife:
~5 hours in extensive CYP2D6 metabolizers; ~21 hours in CYP2D6 poor metabolizers'"`UNIQ--ref-00000014-QINU`"' (1)
bioavailability:
~63% (oral; extensive first-pass)'"`UNIQ--ref-00000015-QINU`"' (1)
pregnancy:
Limited human data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. '''Not a controlled substance''', the principal clinical selling point versus psychostimulant ADHD options. Carries the antidepressant-class '''Boxed Warning''' for suicidal ideation in pediatric patients'"`UNIQ--ref-00000016-QINU`"' (1)

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