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Drilldown: Medicines

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Medicines > generic : Butalbital / Aspirin / Caffeine or None & classes: [[:Category:NSAIDs|NSAID (aspirin)]]

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generic: (Click arrow to add another value)
brand:
Fiorinal; with codeine as Fiorinal with Codeine (Schedule III) (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-000015B6-QINU`"' (1)
starting dose:
1-2 capsules (50 mg butalbital / 325 mg aspirin / 40 mg caffeine each) PO every 4 hours as needed; maximum 6 capsules/d (1)
preparations:
50/325/40 mg capsules (1)
fda max:
6 capsules/d (300 mg butalbital, 1950 mg aspirin, 240 mg caffeine) (1)
routes:
Oral (1)
onset:
30-60 minutes (1)
duration:
4-6 hours (1)
halflife:
Butalbital ~35 hours; aspirin (acetyl group) ~15 minutes, salicylate 2-3 hours; caffeine 3-7 hours'"`UNIQ--ref-000015B7-QINU`"' (1)
bioavailability:
Butalbital well-absorbed; aspirin 50-75%; caffeine ~100%'"`UNIQ--ref-000015B8-QINU`"' (1)
pregnancy:
Avoided; barbiturate + aspirin teratogenicity and bleeding concerns.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Schedule III|Schedule III controlled substance]] in US (Fiorinal is scheduled federally; Fioricet with acetaminophen is unscheduled federally despite identical butalbital content, a regulatory quirk) (1)

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