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Medicines > classes: [[:Category:Non-benzodiazepine hypnotics|Non-benzodiazepine hypnotic]] & fda max: 10 mg/day (IR); 12.5 mg/day (CR)

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generic:
Zolpidem (tartrate) (1)
brand:
Ambien (IR), Ambien CR (biphasic-release), Edluar (sublingual), Intermezzo (low-dose sublingual for middle-of-night awakening), Zolpimist (oral spray) (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000017-QINU`"', '"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"' (1)
starting dose:
'''5 mg PO at bedtime for women, 5-10 mg for men''' (per FDA's 2013 sex-specific dose reduction for women due to slower clearance). Ambien CR 6.25 mg women / 6.25-12.5 mg men. Intermezzo SL 1.75 mg women / 3.5 mg men (1)
preparations:
IR tablets 5, 10 mg; CR tablets 6.25, 12.5 mg; SL tablets 1.75, 3.5, 5, 10 mg; oral spray (1)
fda max: (Click arrow to add another value)
routes:
Oral (1) · oromucosal spray (1) · sublingual (1)
onset:
15-30 minutes (1)
duration:
6-8 hours (IR); 8 hours (CR via biphasic release) (1)
halflife:
~2.5 hours'"`UNIQ--ref-0000001A-QINU`"' (1)
bioavailability:
~70% (oral)'"`UNIQ--ref-0000001B-QINU`"' (1)
pregnancy:
Limited human data; case reports of neonatal sedation with late-pregnancy exposure.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Schedule IV|Schedule IV controlled substance]] in US. Carries the FDA '''Boxed Warning''' for '''complex sleep behaviors''' (sleep-driving, sleep-walking, sleep-eating, other parasomnias) added in 2019'"`UNIQ--ref-0000001C-QINU`"' (1)

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