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Medicines > generic: Loperamide & classes: [[:Category:Opioid_receptor_agonists|Peripheral opioid receptor agonist (μ-selective

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generic: (Click arrow to add another value)
brand:
Imodium, Imodium A-D (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000FCF-QINU`"', '"`UNIQ--vote-00000FD0-QINU`"', '"`UNIQ--vote-00000FD1-QINU`"' (1)
starting dose:
4 mg PO initially, then 2 mg after each loose stool, '''not to exceed 16 mg/d''' (8 mg OTC); chronic-use lower (1)
preparations:
2 mg capsules and tablets; 1 mg/5 mL oral solution; combined with simethicone (Imodium Multi-Symptom) (1)
fda max:
16 mg/d (8 mg/d OTC) (1)
routes:
Oral (1)
onset:
30-60 minutes (1)
duration:
8-12 hours (1)
halflife:
~9-14 hours'"`UNIQ--ref-00000FD2-QINU`"' (1)
bioavailability:
~0.3% (oral; extensive first-pass via CYP3A4 and P-glycoprotein-mediated efflux at the intestinal and blood-brain barriers limit systemic and CNS exposure at therapeutic doses)'"`UNIQ--ref-00000FD3-QINU`"' (1)
pregnancy:
Generally considered acceptable when needed.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1)

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