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Medicines > classes: [[:Category:Polyene_antifungals|Polyene antifungal]] & fda max : 600 mg/d or Indication-specific

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generic:
Nystatin (1)
brand:
Mycostatin, Nystop, Nyamyc, Bio-Statin (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-00000D11-QINU`"' Same mechanistic family as amphotericin B but with prohibitive systemic toxicity at therapeutic doses, hence restriction to topical and luminal-gut indications. No clinically meaningful resistance after decades of use'"`UNIQ--ref-00000D12-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000D13-QINU`"', '"`UNIQ--vote-00000D14-QINU`"', '"`UNIQ--vote-00000D15-QINU`"', '"`UNIQ--vote-00000D16-QINU`"' (1)
starting dose:
Oral: 4-6 mL (400,000-600,000 units) suspension QID swish-and-swallow; topical: BID-QID; vaginal tablet 1 daily for 2 weeks (1)
preparations:
100,000 units/mL oral suspension; 500,000 unit tablets; 100,000 units/g cream, ointment, powder; vaginal tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (topical action; minimal systemic absorption) (1) · topical (1) · vaginal (1)
onset:
Symptom relief within days (1)
duration:
Hours per application (1)
halflife:
Not meaningfully described (not systemically absorbed)'"`UNIQ--ref-00000D17-QINU`"' (1)
bioavailability:
Essentially zero systemic absorption from oral or topical routes — the topical-action-only profile is the basis of its safety'"`UNIQ--ref-00000D18-QINU`"' (1)
pregnancy:
Generally considered safe in pregnancy (no systemic absorption).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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