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Medicines > classes: [[:Category:Second-generation neuroleptics|Second-generation (atypical) neuroleptic]] & fda max: 800 mg/day

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generic:
Quetiapine (1)
brand:
Seroquel (1)
classes: (Click arrow to add another value)
mechanism:
Dopamine D2 and serotonin 5-HT2A receptor antagonist'"`UNIQ--ref-0000008D-QINU`"' '"`UNIQ--vote-0000008E-QINU`"' (1)
uses:
'"`UNIQ--vote-0000008F-QINU`"', '"`UNIQ--vote-00000090-QINU`"', '"`UNIQ--vote-00000091-QINU`"', '"`UNIQ--vote-00000092-QINU`"' (1)
starting dose:
25 mg (schizophrenia, immediate-release); 50 mg (bipolar mania, immediate-release); 50 mg (Seroquel XR, schizophrenia or bipolar) (1)
preparations:
25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg immediate-release tablets; 50 mg, 150 mg, 200 mg, 300 mg, 400 mg extended-release tablets (Seroquel XR) (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
30-60 min (sedation); days to weeks (neuroleptic effect) (1)
duration:
6-8 h (immediate-release); 24 h (extended-release) (1)
halflife:
~6 h (parent compound, immediate-release); ~9-12 h (active metabolite N-desalkylquetiapine, also called norquetiapine) (1)
bioavailability:
Tablet ~100% relative to oral solution; extensive first-pass metabolism (1)
pregnancy:
Pregnancy categories were retired by FDA in 2015. Quetiapine has reassuring active-comparator cohort data without consistent teratogenic signal; among the preferred neuroleptics when treatment is clinically necessary in pregnancy. See pregnancy_details for the full citation set. (1)
legal:
[[USLegal:Prescription only|Prescription only]]; not a controlled substance (1)

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