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Medicines > classes: [[:Category:Sex_hormones|Sex hormone]] & fda max: Indication-specific & routes: IM

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generic:
Medroxyprogesterone acetate (MPA) (1)
brand:
Provera (oral), Depo-Provera (IM contraceptive), Depo-SubQ Provera 104 (SC) (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000F1B-QINU`"', '"`UNIQ--vote-00000F1C-QINU`"', '"`UNIQ--vote-00000F1D-QINU`"', '"`UNIQ--vote-00000F1E-QINU`"', '"`UNIQ--vote-00000F1F-QINU`"' (1)
starting dose:
Contraception: Depo-Provera 150 mg IM every 13 weeks; Depo-SubQ 104 mg SC every 12-13 weeks; oral cycling: 5-10 mg PO daily ×5-10 days for amenorrhea (1)
preparations:
2.5, 5, 10 mg oral tablets; Depo-Provera 150 mg/mL IM; Depo-SubQ Provera 104 mg/0.65 mL (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Contraceptive within 24 hours if given in first 5 days of cycle; otherwise backup for 7 days (1)
duration:
Depot IM 13 weeks (designed); often persists longer (1)
halflife:
~50 days (Depo-Provera; long depot release)'"`UNIQ--ref-00000F20-QINU`"' (1)
bioavailability:
Oral ~90%; depot IM essentially 100% over the dosing interval'"`UNIQ--ref-00000F21-QINU`"' (1)
pregnancy:
Contraindicated in known pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' for bone mineral density loss with prolonged use (≥2 years; partially reversible after discontinuation)'"`UNIQ--ref-00000F22-QINU`"' (1)

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