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Drilldown: Medicines

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Medicines > classes: [[:Category:Sigma-1_receptor_agonists|Sigma-1 receptor agonist]] & fda max: N/A (no current medical indication)

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generic:
Phencyclidine (1)
brand:
Sernyl (human, withdrawn 1965); Sernylan (veterinary, withdrawn 1978) (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000063-QINU`"', '"`UNIQ--vote-00000064-QINU`"' (1)
starting dose:
No current medical indication. Historical anesthetic dose 0.25 mg/kg IV (Sernyl). (1)
preparations:
Historical: Sernyl 25 mg tablets, 10 mg/mL injection (human); Sernylan 100 mg/mL injection (veterinary). Illicit: white crystalline powder, oily liquid, "dipped" cigarettes ("wet"), tablets. (1)
fda max: (Click arrow to add another value)
routes:
IM (1) · insufflated (1) · IV (1) · Oral (1) · smoked (1)
onset:
Smoked 2-5 min; insufflated 5-15 min; oral 30-60 min; IV / IM ~5-15 min (1)
duration:
4-8 hours typical; longer at high doses; residual cognitive and perceptual effects up to 48 hours (1)
halflife:
Highly variable, 7-46 hours (mean ~21 h); lipophilic deposition in fat with delayed re-release contributes to wide range'"`UNIQ--ref-00000065-QINU`"' (1)
bioavailability:
~72% oral; ~85% smoked'"`UNIQ--ref-00000066-QINU`"' (1)
pregnancy:
None (1)
legal:
[[USLegal:DEA Schedule II|Schedule II]] controlled substance in US (rescheduled from Schedule III in 1978). No accepted medical use. UN Convention on Psychotropic Substances Schedule II internationally.'"`UNIQ--ref-00000067-QINU`"' (1)

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