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Medicines > classes: [[:Category:Statins|Statin]] & halflife: ~19 hours'"`UNIQ--ref-000000FC-QINU`"'

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generic:
Rosuvastatin (1)
brand:
Crestor, Ezallor (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-000000F7-QINU`"' Minimal CYP3A4 dependence (CYP2C9 minor) reduces drug-drug interactions; transport in and out of hepatocytes is largely via OATP1B1, making SLCO1B1 PGx genotype the most clinically actionable marker for statin-associated myopathy'"`UNIQ--ref-000000F8-QINU`"'. (1)
uses:
'"`UNIQ--vote-000000F9-QINU`"', '"`UNIQ--vote-000000FA-QINU`"', '"`UNIQ--vote-000000FB-QINU`"' (1)
starting dose:
10-20 mg PO once daily (5 mg in Asian ancestry, elderly, hypothyroidism, or strong CYP/SLCO1B1 interactions) (1)
preparations:
5, 10, 20, 40 mg tablets (1)
fda max:
40 mg/d (rarely needed; 40 mg restricted to patients not at goal on 20 mg) (1)
routes:
Oral (1)
onset:
LDL lowering at 1 week, max by 4 weeks (1)
duration:
24 hours (1)
halflife: (Click arrow to add another value)
bioavailability:
~20% (oral; hydrophilic, minimal CYP metabolism, mostly excreted unchanged in bile)'"`UNIQ--ref-000000FD-QINU`"' (1)
pregnancy:
Previously Category X; FDA removed the blanket statin contraindication in pregnancy in 2021. Use individualized.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)
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