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Medicines > classes: [[:Category:Tetracyclic antidepressants|Tetracyclic antidepressant]] & fda max: 45 mg/day

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generic:
Mirtazapine (1)
brand:
Remeron (US brand discontinued; generic widely available), Remeron SolTab (ODT) (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"' (1)
starting dose:
15 mg PO at bedtime, titrate to 30-45 mg/day after 1-2 weeks. '''Counterintuitive dose paradox''': lower doses (7.5-15 mg) are more sedating than higher doses because H1 antihistamine effect dominates at low dose (1)
preparations:
Tablets 7.5, 15, 30, 45 mg; orally disintegrating tablets (SolTab) 15, 30, 45 mg (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Sleep effect from first dose; antidepressant effect over 1-4 weeks (1)
duration:
24 hours (HS dosing) (1)
halflife:
20-40 hours'"`UNIQ--ref-00000023-QINU`"' (1)
bioavailability:
~50% (oral; substantial first-pass)'"`UNIQ--ref-00000024-QINU`"' (1)
pregnancy:
Limited human data; some observational signals reassuring relative to other antidepressants.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000025-QINU`"' (1)

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