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Medicines > classes: [[:Category:Thionamides|Thionamide]] & fda max : 60 mg/d typical or TID per eye

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generic:
Methimazole (thiamazole) (1)
brand:
Tapazole; outside US Mercazole (1)
classes: (Click arrow to add another value)
mechanism:
'"`UNIQ--vote-00000ECD-QINU`"' Agranulocytosis is the most-feared adverse effect (~0.3%, usually first 90 days of treatment; warn patients to seek urgent CBC for fever or severe sore throat). Hepatotoxicity is class-recognized but more often associated with PTU'"`UNIQ--ref-00000ECE-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000ECF-QINU`"', '"`UNIQ--vote-00000ED0-QINU`"', '"`UNIQ--vote-00000ED1-QINU`"', '"`UNIQ--vote-00000ED2-QINU`"' (1)
starting dose:
10-40 mg PO daily depending on hyperthyroidism severity; titrate by clinical and biochemical response (target TSH/free T4) (1)
preparations:
5, 10 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Biochemical improvement within 2-4 weeks; full euthyroid state 6-12 weeks (1)
duration:
24 hours (1)
halflife:
~4-6 hours (plasma); intrathyroidal accumulation gives a much longer functional duration'"`UNIQ--ref-00000ED3-QINU`"' (1)
bioavailability:
~93% (oral)'"`UNIQ--ref-00000ED4-QINU`"' (1)
pregnancy:
None (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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