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Medicines > classes: Anti-CGRP ligand monoclonal antibody & onset: Over weeks & duration: Monthly dosing

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generic:
None (1)
brand:
Emgality (1)
classes: (Click arrow to add another value)
mechanism:
Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1)
uses:
Preventive treatment of migraine in adults; episodic cluster headache (1)
starting dose:
Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1)
preparations:
120 mg/mL prefilled syringe or autoinjector (1)
fda max:
240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1)
routes:
Subcutaneous (1)
onset: (Click arrow to add another value)
duration: (Click arrow to add another value)
halflife:
~27 days (1)
bioavailability:
Not formally established (high SC) (1)
pregnancy:
Limited data; avoid (1)
legal:
Rx (1)

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