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Medicines > classes: Anti-CGRP ligand monoclonal antibody & halflife : ~27 days or ~6 hours plasma; long bone retention

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generic:
None (2)
brand:
Emgality (1) · Vyepti (1)
classes: (Click arrow to add another value)
mechanism:
Humanized IgG1 monoclonal antibody binding CGRP peptide; IV infusion enables fastest onset of any CGRP mAb (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1)
uses:
Preventive treatment of migraine in adults (1) · Preventive treatment of migraine in adults; episodic cluster headache (1)
starting dose:
100 mg IV every 3 months; may increase to 300 mg IV every 3 months (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1)
preparations:
100 mg/mL vial for IV infusion (1) · 120 mg/mL prefilled syringe or autoinjector (1)
fda max:
240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1) · 300 mg/quarter (1)
routes:
Intravenous infusion (1) · Subcutaneous (1)
onset:
Effect demonstrated within 24 hours in some patients (1) · Over weeks (1)
duration:
3-month dosing interval (1) · Monthly dosing (1)
halflife: (Click arrow to add another value)
bioavailability:
100% (IV) (1) · Not formally established (high SC) (1)
pregnancy:
Limited data; avoid (2)
legal:
Rx (2)

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