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Medicines > classes: Anti-CGRP receptor monoclonal antibody & duration : Monthly dosing or ~7-8 hours

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generic:
None (1)
brand:
Aimovig (1)
classes: (Click arrow to add another value)
mechanism:
Humanized IgG2 monoclonal antibody binding the CGRP receptor (not the peptide); blocks CGRP-mediated vasodilation and nociceptive signaling (1)
uses:
Preventive treatment of migraine in adults (episodic and chronic) (1)
starting dose:
70 mg SC monthly; may increase to 140 mg monthly (1)
preparations:
70 mg/mL or 140 mg/mL prefilled autoinjector (1)
fda max:
140 mg/month (1)
routes:
Subcutaneous (1)
onset:
Onset of preventive effect over weeks; some patients respond after first dose (1)
duration: (Click arrow to add another value)
halflife:
~28 days (1)
bioavailability:
~82% SC (1)
pregnancy:
Limited data; avoid (1)
legal:
Rx (1)

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