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Drilldown: Medicines

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Medicines > classes: Anxiolytic

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generic:
Alprazolam (1) · Bromazepam (1) · Chlordiazepoxide (1) · Clorazepate (1) · Duloxetine (1) · Etizolam (1) · Kava (1) · Meprobamate (1) · Metizolam (1) · Oxazepam (1) · Pyrazolam (1) · Sertraline (1)
brand:
None (4) · Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Lexotan (1) · Librium (1) · Miltown (1) · Serax (1) · Tranxene (1) · Xanax (1) · Zoloft (1)
classes: (Click arrow to add another value)
mechanism:
GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · GABAA modulator; glycine receptor agonist (1) · GABAA positive allosteric modulator (5) · GABAA positive allosteric modulator; low sedation (1) · GABAA positive allosteric modulator; prodrug of desmethyldiazepam (1) · Kavalactones; GABAA modulator; sigma receptor activity (1) · Serotonin–norepinephrine reuptake inhibition (balanced) (1) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1)
uses:
None (10) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
None (10) · 0.25 mg (1) · 25 mg (1)
preparations:
None (10) · 0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1)
fda max:
None (10) · 10 mg/d (1) · 200 mg/d (1)
routes:
None (9) · Oral (3)
onset:
None (9) · 30-60 min (immediate-release); 1-2 h (extended-release) (1) · Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1)
duration:
None (9) · 6 h (immediate-release); ~11 h (extended-release) (1) · Chronic daily dosing (1) · Long (1)
halflife:
None (9) · 11-13 h (immediate-release); 11-16 h (extended-release) (1) · ~12 hours (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1)
bioavailability:
None (9) · 80-90% oral (1) · Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · ~50% (highly variable) (1)
pregnancy:
None (9) · Category C (1) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1)
legal:
None (9) · Rx-only (1) · Rx-only in US (1) · Schedule IV (US) (1)

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