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Drilldown: Medicines

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Medicines > classes: Cardioselective (β1) & fda max : 400 mg/d or Titrated to glucose; no fixed ceiling

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generic:
Metoprolol (1)
brand:
Lopressor (tartrate), Toprol XL (succinate) (1)
classes: (Click arrow to add another value)
mechanism:
Cardioselective β1-adrenergic antagonist. Selectivity is dose-dependent and partially lost at higher doses. (1)
uses:
'"`UNIQ--vote-000004F5-QINU`"', '"`UNIQ--vote-000004F6-QINU`"', '"`UNIQ--vote-000004F7-QINU`"', '"`UNIQ--vote-000004F8-QINU`"', '"`UNIQ--vote-000004F9-QINU`"' (1)
starting dose:
25–50 mg BID (tartrate); 25–100 mg daily (succinate); 12.5 mg daily in HFrEF (1)
preparations:
Tartrate: 25, 50, 100 mg tabs; 1 mg/mL IV. Succinate ER: 25, 50, 100, 200 mg. (1)
fda max: (Click arrow to add another value)
routes:
IV (1) · Oral (1)
onset:
1–2 h (PO); immediate (IV) (1)
duration:
6–12 h (tartrate); 24 h (succinate) (1)
halflife:
3–7 h (1)
bioavailability:
~50% (1)
pregnancy:
Category C (1)
legal:
Rx-only in US (1)

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