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Medicines > classes: Cardioselective (β1) + vasodilator & onset : 1–2 h or BP effect within 1-2 weeks

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generic:
Nebivolol (1)
brand:
Bystolic (1)
classes: (Click arrow to add another value)
mechanism:
The d-enantiomer is a highly β1-selective antagonist; the l-enantiomer triggers endothelial nitric-oxide–mediated vasodilation. Unique among beta blockers for this NO mechanism. (1)
uses:
'"`UNIQ--vote-0000059D-QINU`"' (1)
starting dose:
5 mg daily (1)
preparations:
2.5, 5, 10, 20 mg tabs (1)
fda max:
40 mg/d (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
24 h (1)
halflife:
~10 h (CYP2D6 extensive metabolizers); up to 31 h (poor metabolizers) (1)
bioavailability:
~12% (extensive metabolizers); ~96% (poor metabolizers) (1)
pregnancy:
Category C (1)
legal:
Rx-only in US (1)

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