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Medicines > classes: Combined cholinesterase inhibitor + NMDA antagonist & onset: Component effects accumulate over weeks

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generic:
Memantine ER / Donepezil (1)
brand:
Namzaric (1)
classes: (Click arrow to add another value)
mechanism:
Donepezil: reversible AChE inhibitor, increases synaptic acetylcholine. Memantine: uncompetitive low-affinity NMDA receptor antagonist, dampens pathological glutamate overactivation while preserving normal synaptic signaling. Targets two distinct mechanisms in Alzheimer's. (1)
uses:
'"`UNIQ--vote-00000468-QINU`"' (1)
starting dose:
For patients already stable on memantine 28 mg/d + donepezil 10 mg/d, switch to one capsule daily of equivalent strength (1)
preparations:
7/10, 14/10, 21/10, 28/10 mg ER capsules (memantine ER / donepezil) (1)
fda max:
28/10 mg/d (1)
routes:
Oral (capsule whole or opened/sprinkled on applesauce) (1)
onset: (Click arrow to add another value)
duration:
24 h (1)
halflife:
~60–80 h (memantine); ~70 h (donepezil) (1)
bioavailability:
~100% both components (1)
pregnancy:
Not relevant (geriatric problem) (1)
legal:
Rx-only in US (1)

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