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Medicines > classes: Dual orexin receptor antagonist (DORA) & halflife: ~17-19 hours (longer than daridorexant)

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generic:
None (1)
brand:
Dayvigo (1)
classes: (Click arrow to add another value)
mechanism:
Competitive antagonist at OX1R and OX2R. Faster receptor association/dissociation kinetics than suvorexant (~16 sec dissociation vs ~57 sec) hypothesized to support sleep onset, with sufficient duration for maintenance. (1)
uses:
Insomnia (sleep onset and/or maintenance) in adults (FDA-approved Dec 2019) (1)
starting dose:
5 mg PO at bedtime; may increase to 10 mg if inadequate (1)
preparations:
5 mg, 10 mg tablets (1)
fda max:
10 mg/d (1)
routes:
Oral (1)
onset:
~30 min (1)
duration:
~7-8 hours (1)
halflife: (Click arrow to add another value)
bioavailability:
~44% (1)
pregnancy:
Limited data; avoid (1)
legal:
Rx, Schedule IV (US) (1)

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